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진료과

  • 연세암병원-종양내과, 간암센터, 대장암센터

전문진료분야

  • <종양내과> 대장암, 간암, 항암약물치료, 신약치료

교육 및 임상 경력

  • 2008-2009  연세대학교  의과대학  세브란스병원  인턴  수료
  • 2009-2013  연세대학교  의과대학  세브란스병원  내과  레지던트  수료
  • 2013-2018  연세대학교  의과대학  의과학자  양성  과정  수료  (Physician-Scientist  Program)
  • 2016-2018  코넬  의대  Research  Fellow
  • 2018-2019  연세대학교  의과대학  내과학교실  종양내과  강사
  • 2019-현  재  연세대학교  의과대학  내과학교실  종양내과  임상조교수

학술관련경력

  • [학회활동]
  • American Society of Clinical Oncology 회원
  • American Association for Cancer Research 회원
  • European Society for Medical Oncology 회원
  • International Society for Extracellular Vesicles 회원
  • Metastasis Research Society 회원
  • 대한암학회 회원
  • 대한종양내과학회 회원
  • 대한항암요법연구회 회원
  • 대학약리학회 회원
  • 대한내과학회 회원
  • 서울시의사회 회원
  • 연세간암연구회
  • [수상경력]
  • 2000 연세 정보올림피아드 금상
  • 2005 LG Global Challenger 우수상 - "세포 하나가 환자가 된다 - 나노의학"
  • 2007 연세대학교 의과대학 학생 연구비 선정
  • 2009 내과 우수 전공의
  • 2010 내과 우수 전공의
  • 2010 연세대학교 의과대학 내과총동우회 전공의 학술상
  • 2011 국제 위암학회 우수 포스터상
  • 2012 국제 아시아 임상 암학회 Merit Award
  • 2012 MASCC/ISOO 국제 완화 의료 학회 젊은 연구자상
  • 2012 연세대학교 대학원 석사 우수 학술상
  • 2013 한국 암연구재단, 우수연구상
  • 2014 미국 암학회 AACR-GlaxoSmithKline Outstanding Clinical Scholar Award
  • 2015 한국임상암학회 보령학술상 젊은연구자상
  • 2016 서울시 의사회 젊은 연구자상
  • 2018 연세대학교 대학원 박사 최우수 학술상
  • 2018 대한종양내과학회 학술연구비상
  • 2018 연세대학교 의과대학 내과학교실 학술연구비 선정
  • 2018 대한종양내과학회 제 11차 학술대회 우수 Presentation상

주요 관심분야

  • Exosome, Cancer Metastasis, Pre-metastatic niche

학력사항

  • 연세대학교 의과대학 의학과 학사 (2008)
  • 연세대학교 의과대학 의학과 석사 (2012)
  • 연세대학교 의과대학 의학과 박사 (2018)

논문

  • * First Author
  • 1. Kim S*, Kim HS*, Kim E, Lee MG, Shin E, Paik S, Kim S. Neopepsee: accurate genome-level prediction of neoantigens by harnessing sequence and amino acid immunogenicity information. Ann Oncol. 2018. 1;29(4):1030-1036. *co-first
  • 2. Matei I*, Kim HS*, Lyden D. Unshielding exosomal RNA unleashes tumor growth and metastasis. Cell. 2017;170(2):223-225. *co-first
  • 3. Kim HS*, Cheon JH*, Jung ES*, Park J, Aum S, Park SJ, Eun S, Lee J, Ruther U, Yeo GS, Ma M, Park KS, Naito T, Kakuta Y, Lee JH, Kim WH, Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut. 2017;66(11):1926-1935. *co-first
  • 4. Kim HS*, Jung M*, Kang HN*, Kim H, Park CW, Kim SM, Shin SJ, Kim SH, Kim SG, Kim EK, Yun MR, Zheng Z, Chung KY, Greenbowe J, Ali SM, Kim TM, Cho BC. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. Oncogene. 2017;36(23):3334-3345. *co-first
  • 5. Kim HS, Kwon HJ, Jung I, Yun MR, Ahn MJ, Kang BW, Sun JM, Kim SB, Yoon DH, Park KU, Lee SH, Koh YW, Kim SH, Choi EC, Koo DH, Sohn JH, Kim B, Kwon NJ, Yun HJ, Lee MG, Lee JH, Kim TM, Kim HR, Kim JH, Paik S, Cho BC. Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck. Clin Cancer Res. 2015;21(3):544-52. “Highlights” Selected Articles from CCR Vol. 21 Num. 3
  • 6. Yoon JK*, Ahn J*, Kim HS*, Han SM, Jang H, Lee MG, Lee JH, Bang D. microDuMIP: target-enrichment technique for microarray-based duplex molecular inversion probes. Nucleic Acids Res. 2015;43(5). *co-first
  • 7. Jung J*, Kim HS*, Lee MG, Yang EJ, Choi JY, Novel COCH p.V123E mutation, causative of DFNA9 sensorineural hearing loss and vestibular disorder, shows impaired cochlin post-translational cleavage and secretion. Hum Mutat. 2015;36(12):1168-75. *co-first
  • 8. Ahn JW*, Kim HS*, Yoon JK*, Jang H, Han SM, Eun S, Shim HS, Cho BC, Lee JH, Bang D, et al. Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers. Genome Medicine. 2014;6(2):18 *co-first
  • 9. Kim HS, Tetsuya Mitsudomi, Ross A. Soo, Cho BC. Personalized therapy on the horizon for squamous cell carcinoma of the lung, Lung Cancer. 2013;80 (3):249-55.
  • 10. Kim HS, Lee S, et al. Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced Solid Tumor, Support Care Cancer. 2013;21(6):1751-9.
  • 11. Kim HS, Shin SJ, Kim JH, Kim H, Choi HJ. Better Outcome of XELOX Chemotherapy in Patients with Advanced Intestinal-Type Adenocarcinoma of the Ampulla of Vater. Tohoku J Exp Med. 2013;231(1):21-8
  • 12. Kim HS*, Kim SC*, Kim SJ, Park CH, Jeung HC, Kim YB, Ahn JB, Chung HC, Rha SY, Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells. BMC Genomics. 2012;13(1):348. *co-first
  • 13. Kim HS, Kim HR, Kim GM, Kim HS, Koh YW, Kim SH, Choi EC, Hong YK, Sung JH, Kim SM, Kim JH, Cho BC. The Efficacy and Toxicity of S-1 and Cisplatin as First-line Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma. Cancer Chemother Pharmacol. 2012 Oct;70(4):539-46.
  • 14. Kim HS, Kang SH, Park CH, Yang WI, Jeung HC, Chung HC, Roh JK, Ahn JB, Kim NK, Min BS, Rha SY. Genome-wide molecular characterization of mucinous colorectal adenocarcinoma using cDNA microarray analysis. Oncol Rep. 2011;25(3):717-27.
  • 15. Kim HS, Pak HN, Park JS, Kim SS. Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia. Pacing Clin Electrophysiol. 2013;36(3):e84-6.
  • 16. Kim HS, Chon HJ, Kim H, Shin SJ, Wacheck V, Gruver AM, Kim JS, Rha SY, Chung HC. MET in gastric cancer with liver metastasis: The relationship between MET amplification and Met overexpression in primary stomach tumors and liver metastasis. J Surg Oncol;117(8):1679-1686
  • * Contributing author
  • 1. Zhang H, Freitas D*, Kim HS*, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific C, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhaes A, Ferreira JA, Osorio H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of novel nanoparticles and distinct exosome subsets via asymmetric-flow field-flow fractionation. Nat Cell Biol. 2018. Accepted. *co-second
  • 2. Becker A*, Thakur BK*, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. Cancer Cell. 2016;30(6):836-848.
  • 3. Kim W, Lee S, Kim HS, Song M, Cha YH, Kim YH, Shin J, Lee ES, Joo Y, Song JJ, Choi EJ, Choi JW, Lee J, Kang M, Yook JI, Lee MG, Kim YS, Paik S. Kim HH. Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Genome Res. 2018. Epub.
  • 4. Huang KK*, Jang KW*, Kim S, Kim HS, Kim SM, Kwon HJ, Kim HR, Yun HJ, Ahn MJ, Park KU, Ramnayanan K, McPherson J, Zhang S, Rhee J, Vettore A, Das K, Ishimoto T, Kim J, Koh YW, Kim SH, Choi EC, Teh BT, Rozen S, Kim T, Tan P. Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck. Scientific Reports. 2016;21(6):19552.
  • 5. Kim GM, Ahn JB, Rha SY, Kim HS, Kang B, Kim MW, Choi SY, Roh JK, Chung HC, Kim NK, Shin SJ. Changing Treatment Patterns in Elderly Patients with Resectable Colon Cancer. Asia-Pacific Journal of Clinical Oncology. 2013;9(3):265-72.
  • 6. Lim S, Cho BC, Jung JY, Kim GM, Kim SH, Kim HR, Kim HS, Lim SM, Park JS, Lee JH, Kim D, Kim EY, Park MS, Kim YS, Kim SK, Chang J, Kim JH. Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer. Lung Cancer. 2013;80(3):313-8.
  • 7. Leem AY, Kim HS, Yoo BW, Kang BD, Kim MH, Rha SY, and Kim HS. Ifosfamide-induced Fanconi syndrome with diabetes insipidus. Korean J Intern Med. 2014;29(2):246-249.
  • 8. Rim HT*, Byun IH*, Kim HS, Lee SY, Yoon JS. Factors associated with diabetic retinopathy and nephropathy screening in Korea: The Third and Fourth Korea National Health and Nutrition Examination Survey (KNHANES III and IV). J Korean Med Sci. 2013;28(6):814-20.
  • 9. Wittkowski KM, Dadurian C, Seybold MP, Kim HS, Hoshino A, Lyden D. Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer. PLoS One. 2018;13(7):e0199012
  • Genome-wide molecular characterization of mucinous colorectal adenocarcinoma using cDNA microarray analysis
    ONCOLOGY REPORTS 25/3 :717-727,2011
  • Identification of a radiosensitivity signature using integrative metaanalysis of published microarray data for NCI-60 cancer cells
    BMC GENOMICS 13/348 :-,2012
  • The efficacy and toxicity of S-1 and cisplatin as first-line chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma
    CANCER CHEMOTHERAPY AND PHARMACOLOGY 70/4 :539-546,2012
  • Phase II study of camtobell inj. (belotecan) in combination with cisplatin in patients with previously untreated, extensive stage small cell lung cancer
    LUNG CANCER 80/3 :313-318,2013
  • Factors Associated with Diabetic Retinopathy and Nephropathy Screening in Korea: The Third and Fourth Korea National Health and Nutrition Examination Survey (KNHANES III and IV)
    JOURNAL OF KOREAN MEDICAL SCIENCE 28/6 :814-820,2013
  • Randomized controlled trial of standardized education and telemonitoring for pain in outpatients with advanced solid tumors
    SUPPORTIVE CARE IN CANCER 21/6 :1751-1759,2013
  • Changing treatment patterns in elderly patients with resectable colon cancer
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 9/3 :265-272,2013
  • Personalized therapy on the horizon for squamous cell carcinoma of the lung
    LUNG CANCER 80/3 :249-255,2013
  • Flecainide-Associated Bradycardia-Dependent Torsade de Pointes: Another Potential Mechanism of Proarrhythmia
    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY 36/3 :e84-e86,2013
  • Better Outcome of XELOX Chemotherapy in Patients with Advanced Intestinal-Type Adenocarcinoma of the Ampulla of Vater
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 231/ :21-28,2013
  • Ifosfamide-induced Fanconi syndrome with diabetes insipidus
    KOREAN JOURNAL OF INTERNAL MEDICINE 29/2 :246-249,2014
  • Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
    GENOME MEDICINE 6/18 :1-10,2014
  • Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
    CLINICAL CANCER RESEARCH 21/3 :544-552,2015
  • microDuMIP: target-enrichment technique for microarray-based duplex molecular inversion probes
    NUCLEIC ACIDS RESEARCH 43/5 :e28-e28,2015
  • Novel COCH p.V123E Mutation, Causative of DFNA9 Sensorineural Hearing Loss and Vestibular Disorder, Shows Impaired Cochlin Post-Translational Cleavage and Secretion
    HUMAN MUTATION 36/12 :1168-1175,2015
  • Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
    SCIENTIFIC REPORTS 6/ :19552-,2016
  • Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
    CANCER CELL 30/6 :836-848,2016
  • Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition.
    ONCOGENE 36/23 :3,334-3,345,2017
  • A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.
    GUT 66/11 :1,926-1,935,2017
  • Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis
    CELL 170/2 :223-225,2017
  • Neopepsee: accurate genome-level prediction of neoantigens by harnessing sequence and amino acid immunogenicity information
    ANNALS OF ONCOLOGY 29/4 :1,030-1,036,2018
  • Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth
    GENOME RESEARCH 28/3 :374-382,2018
  • MET in gastric cancer with liver metastasis: The relationship between MET amplification and Met overexpression in primary stomach tumors and liver metastasis
    JOURNAL OF SURGICAL ONCOLOGY 117/8 :1,679-1,686,2018
  • Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
    NATURE CELL BIOLOGY 20/3 :332-343,2018
  • Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer
    PLOS ONE 13/7 :e0199012-e0199043,2018

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