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진료과

  • 의과대학-내과학교실, 내분비내과, 당뇨병센터, 내분비내과

전문진료분야

  • [강의분야] 대사, 면역학 [연구관심분야] ○ 자가포식, 세포 사멸 ○ 대사/내분비학 ○ 면역/염증

진료시간표

인터넷진료예약
의사시간표
진료시간
오전 본관
오후

논문

  • IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
    JOURNAL OF IMMUNOLOGY 166/7 :4481-4489,2001
  • IFNg sensitizes ME-180 human cervical cancer cells to TNFa-induced apoptosis by inhibiting cytoprotective NF-kB activation
    FEBS LETTERS 495/1-2 :66-70,2001
  • IFN gamma/TNF alpha synergism in MHC class II induction: effect of nicotinamide on MHC class II expression but not on islet-cell apoptosis
    DIABETOLOGIA 45/3 :385-393,2002
  • Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis
    ONCOGENE 21/20 :3139-3148,2002
  • Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1 alpha gene in a Korean family with MODY3
    DIABETOLOGIA 46/5 :721-727,2003
  • Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes
    DIABETOLOGIA 46/9 :1220-1227,2003
  • Resistance of mitochondrial DNA-depleted cells against cell death - Role of mitochondrial superoxide dismutase
    JOURNAL OF BIOLOGICAL CHEMISTRY 279/9 :7512-7520,2004
  • Catecholamine cardiomyopathy associated with paraganglioma rescued by percutaneous cardiopulmonary support - Inverted takotsubo contractile pattern
    CIRCULATION JOURNAL 71/12 :1993-1995,2007
  • NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia
    The Journal of biological chemistry 285/13 :9706-9715,2010
  • Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
    NATURE MEDICINE 19/ :83-92,2013
  • Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
    MOLECULAR CELL 51/ :618-631,2013
  • Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
    PLOS ONE 8/ :-,2013
  • Role of hypothalamic autophagy in the control of whole body energy balance
    REVIEWS IN ENDOCRINE & METABOLIC DISORDERS 14/ :377-386,2013
  • Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440/1 :76-81,2013
  • Co-Transplantation of Bone Marrow-Derived Endothelial Progenitor Cells Improves Revascularization and Organization in Islet Grafts
    AMERICAN JOURNAL OF TRANSPLANTATION 13/6 :1,429-1,440,2013
  • Diabetes-Free Survival in Patients Who Underwent Islet Autotransplantation After 50% to 60% Distal Partial Pancreatectomy for Benign Pancreatic Tumors
    TRANSPLANTATION 95/11 :1,396-1,403,2013
  • Non-HDL-cholesterol/HDL-cholesterol is a better predictor of metabolic syndrome and insulin resistance than apolipoprotein B/apolipoprotein A1
    INTERNATIONAL JOURNAL OF CARDIOLOGY 168/ :2,678-2,683,2013
  • Activin A, exendin-4, and glucose stimulate differentiation of human pancreatic ductal cells
    JOURNAL OF ENDOCRINOLOGY 217/3 :241-252,2013
  • Immunotherapeutic Treatment of Autoimmune Diabetes
    CRITICAL REVIEWS IN IMMUNOLOGY 33/3 :245-281,2013
  • Role of pancreatic beta-cell death and inflammation in diabetes
    DIABETES OBESITY & METABOLISM 15/ :141-151,2013
  • Role of autophagy in the progression from obesity to diabetes and in the control of energy balance
    ARCHIVES OF PHARMACAL RESEARCH 36/2 :223-229,2013
  • Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction
    MOLECULAR AND CELLULAR ENDOCRINOLOGY 367/1-2 :1-10,2013
  • PPAR-gamma Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic beta-Cells
    PLOS ONE 8/1 :e50128-,2013
  • TLR3-triggered reactive oxygen species contribute to inflammatory responses by activating signal transducer and activator of transcription-1
    JOURNAL OF IMMUNOLOGY 190/12 :6,368-6,377,2013
  • Germline mutation of Glu70Lys is highly frequent in Korean patients with von Hippel-Lindau (VHL) disease
    JOURNAL OF HUMAN GENETICS 59/9 :488-493,2014
  • Autophagy-a key player in cellular and body metabolism
    NATURE REVIEWS ENDOCRINOLOGY 10/6 :322-337,2014
  • Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes
    JOURNAL OF CLINICAL INVESTIGATION 124/8 :3,311-3,324,2014
  • Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
    NATURE COMMUNICATIONS 5/- :---,2014
  • The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
    AUTOPHAGY 10/5 :785-802,2014
  • Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
    JOURNAL OF BIOLOGICAL CHEMISTRY 289/36 :24,944-24,955,2014
  • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    GUT 63/ :727-735,2014
  • Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
    REVIEWS IN ENDOCRINE & METABOLIC DISORDERS 15/ :11-20,2014
  • Chronic HMGCR/HMG-CoA Reductase Inhibitor Treatment Contributes to Dysglycemia by Upregulating Hepatic Gluconeogenesis through Autophagy Induction.
    AUTOPHAGY 11/11 :2089-2101,2015
  • Gut Microbiota and Metabolic Disorders
    Diabetes and Metabolism Journal 39/3 :198-203,2015
  • FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
    JOURNAL OF ENDOCRINOLOGY 226/1 :R1-R16,2015
  • Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia
    HUMAN MOLECULAR GENETICS 24/25 :7196-7206,2015
  • Effect of mitochondrial stress on the systemic metabolism
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1350/- :61-65,2015
  • New mechanisms of metformin action: Focusing on mitochondria and the gut
    JOURNAL OF DIABETES INVESTIGATION 6/6 :600-609,2015
  • The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes
    CARDIOVASCULAR DIABETOLOGY 14/70 :---,2015
  • Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome
    AMERICAN JOURNAL OF HUMAN GENETICS 96/ :266-274,2015
  • Improved revascularization of islet grafts using an angiogenic monocyte subpopulation derived from spheroid culture of bone marrow mononuclear cells
    AMERICAN JOURNAL OF TRANSPLANTATION 15/6 :1,543-1,554,2015
  • CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
    SCIENTIFIC REPORTS 6/27938 :1-13,2016
  • Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
    AUTOPHAGY 12/8 :1,390-1,403,2016
  • Role of mitochondrial function in cell death and metabolism
    FRONTIERS IN BIOSCIENCE-LANDMARK 21/ :1,233-1,244,2016
  • p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
    NATURE COMMUNICATIONS 7/ :12,030-,2016
  • The orphan nuclear receptor erraγ regulates hepatic cb1 receptor-mediated fibroblast growth factor 21 gene expression
    PLOS ONE 11/7 :e0159425-,2016
  • Secretagogin affects insulin secretion in pancreatic β-cells by regulating actin dynamics and focal adhesion.
    BIOCHEMICAL JOURNAL 473/ :1,791-1,803,2016
  • Autophagy is a major regulator of beta cell insulin homeostasis
    DIABETOLOGIA 59/ :1,480-1,491,2016
  • Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease
    AUTOPHAGY 12/5 :784-800,2016
  • Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance
    ARCHIVES OF PHARMACAL RESEARCH 39/99 :1503-1518,2016
  • Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice
    AUTOPHAGY 12/12 :2,326-2,343,2016
  • Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis
    GASTROENTEROLOGY 150/4 :815-818,2016
  • Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated mediated activation of autophagy and NLRP3 inflammasome inhibition
    AUTOPHAGY 13/10 :1,767-1,781,2017
  • Alterations in gut microbiota and immunity by dietary fat
    YONSEI MEDICAL JOURNAL 58/6 :1,083-1,091,2017
  • Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis
    PLOS ONE 12/11 :e0187515-,2017
  • A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
    NATURE COMMUNICATIONS 9/1 :1,438-,2018
  • Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice
    SCIENTIFIC REPORTS 8/1 :6,789-6,802,2018
  • The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes
    MOLECULES AND CELLS 41/1 :11-17,2018
  • Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches
    Frontiers in Endocrinology 9/ :485-499,2018
  • Nonsynonymous Variants in PAX4 and GLP1R Are Associated With Type 2 Diabetes in an East Asian Population
    DIABETES 67/9 :1,892-1,902,2018
  • Atg7-dependent canonical autophagy regulates the degradation of aquaporin 2 in prolonged hypokalemia
    SCIENTIFIC REPORTS 9/1 :3,021-,2019
  • Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
    CELL DEATH & DISEASE 10/2 :78-,2019
  • Autophagy in FOXD1 stroma-derived cells regulates renal fibrosis through TGF-β and NLRP3 inflammasome pathway
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 508/3 :965-972,2019
  • β-cell autophagy: Mechanism and role in β-cell dysfunction
    MOLECULAR METABOLISM 27/ :S92-S103,2019

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